Lupus Autoimmunity

Program Updated August 26, 2008

 

Monday, September 8, 2008

 

7:30 am Registration

 

Session I - B Cell Autoimmunity

Session Chair - Mark Shlomchik

 

8:30 am Introductory Remarks

Mark Mamula

 

8:40 am Genes for Human Lupus: Now, What is Their Pathophysiology?

John Harley

 

9:20 am The Structure and Specificity of Edited Autoantibodies

Martin Weigert

 

10:00 am BioSymposia Young Investigator Awards Presentation

 

10:05 am Break

 

10:25 am Tolerance In B Cells After The Heavy Chain Class Switch

David Nemazee

 

11:05 am Activation and Regulation of Autoreactive B Cells

Mark Shlomchik

 

11:45 am Lunch

 

Session II - T Cell Autoimmunity

Session Chair - George Tsokos

 

1:00 pm From SAP-less T Cells To Helpless B Cells and Back: in vivo

Dynamics of Cell Cooperation and The Formation of Germinal Centers

Hai Qi

 

1:40 pm CD4 T Cell Effector Subsets In Autoimmunity

Joseph Craft

 

2:20 pm BioSymposia Young Investigator Awards Presentation

 

2:25 pm Break

 

2:45 pm Immune Cell Signaling In SLE: Novel Therapeutic Targets

George Tsokos

 

3:25 pm Regulation of Th17 Effector Function in Autoimmune Inflammation

Daniel Cua

 

4:05 pm Pathways of Antigen Presentation in Autoimmunity

Mark Mamula

 

4:25 pm Pro-Apoptotic Factors: Bim and Fas Function to Suppress

Spontaneous Development of SLE-like Disease

Harris Perlman

 

4:45 pm BioSymposia Young Investigator Awards Presentation

 

4:50 pm Poster Reception

 

Tuesday, September 9, 2008

 

7:30 - 8:30 am Breakfast

 

Session III - Innate Autoimmunity

Session Chair - Ann Marshak-Rothstein

 

8:30 am Opening Remarks

Joseph Craft

 

8:40 am Role of TLR7 and TLR9 In The Pathogenesis of Lupus

Franck Barrat

 

9:20 am An Inducible Model Of SLE

Ann Marshak-Rothstein

 

10:00 am Interferon-alpha In SLE

Peggy Crow

 

10:40 am BioSymposia Young Investigator Awards Presentation

 

10:45 am Break

 

Session IV - Genetics Of Lupus

Session Chair - Edward Wakeland

 

11:05 am Modeling Genetic Susceptibility to SLE In The Mouse

Edward Wakeland

 

11:45 am Lupus Genes: At the Interface of Tolerance and Autoimmunity

Chandra Mohan

 

12:25 pm Lunch

 

1:30 pm Genome-wide Studies In Human SLE

Tim Behrens

 

2:10 pm Defining Effector and Susceptibility Genes In

Mouse Models of Systemic Autoimmunity

Dwight Kono

 

2:50 pm BioSymposia Young Investigator Awards Presentation

 

2:55 pm Break

 

Session V - Immunotherapeutic Approaches

Session Chair - Gregg Silverman

 

3:15 pm Natural Antiboidy Regulation of Innate Immunity

Gregg Silverman

 

3:55 pm B Cell Targeted Therapies in SLE: Lessons Regarding

Disease Pathogenesis

Jennifer Anolik

 

4:35 pm Using Mouse Models to Dissect Mechanisms of Remission

of SLE Nephritis

Anne Davidson

 

5:15 pm Closing Remarks

 

5:20 pm Adjourn