Sporadic Neurodegeneration

Thursday, July 31, 2008

 

7:00 am Registration, Continental Breakfast

 

Session I – Genetic Analysis of Sporadic and Familial Neurodegeneration 

Robert Brown, Session Chair

 

8:00 am Opening Remarks and Introduction

Robert Brown

 

8:15 am Genetics of Mendelian and Sporadic amyotrophic lateral sclerosis

Robert Brown

 

8:45 am Genetics of Mendelian and Sporadic Parkinson's Disease

David Standaert

 

9:15 am Genetics of Mendelian and Sporadic Alzheimer's Disease

Rudolph Tanzi

 

9:45 am Break

 

Common Factors in Sporadic and Familial Neurodegeneration

 

10:15 am Conformation Specific Antibodies For Detection Of Misfolded

SOD1 In Familial and Sporadic ALS

Jean-Pierre Julien

 

10:45 am Familial and Sporadic Parkinson’s Disease

John Growdon

 

11:15 am Familial and Sporadic Alzheimers’s Disease

Brad Hyman

 

11:45 am TDP-43 In Sporadic and Familial Neurodegernation

Christopher Shaw

 

12:15 pm Open Discussion

 

12:45 pm Lunch

 

Session II – Susceptibility Factors in Sporadic Disease: Epidemiological Insights and Environmental Toxins

Daryl Bosco, Session Chair

 

2:00 p.m. Epidemiology of amyotrophic lateral sclerosis

Lorene Nelson 

 

2:30 p.m. Epidemiology of Parkinson's Disease

Alberto Ascherio

 

3:00 p.m. Epidemiology of Alzheimer's Disease

Richard Mayeux

 

3:30 pm Break

 

4:00 pm Discussion

 

4:30 pm Poster Awards and Reception

 

Friday, August 1, 2008

 

7:30 – 8:15 am Continental Breakfast

 

Session III – Recent Insights into the Pathways and Processes

Involved in Neurodegeneration

Daryl Bosco, Session Chair

 

8:20 am Introductory Remarks

Daryl Bosco

 

8:30 am Axonal Transport in Neurodegeneration

Scott Brady

 

9:00 am RNA Transport and Metabolism in Neural Injury

Mike Fainzilber 

 

9:30 am RNA Transport and Localized Protein Synthesis

in Neurodegeneration

Jeffery Twiss

 

10:00 Aberrant RNA Splicing in amyotrophic lateral sclerosis

Tom Maniatis

 

10:30 am Break

 

11:00 Autophagy

Ana Maria Cuervo

 

11:30 am Sirtuins and Neurodegenerative Diseases

Leonard Guarente

 

12 Noon Lunch

 

Session IV – Selected Recent Approaches to Therapy

Robert Brown, Session Chair

 

1:00 pm Gene Therapy in Neurodegenerative Disorders

Raymond Bartus

 

1:30 pm Gene Therapy in ALS

Brian Kaspar

 

2:00 pm RNAi and Antisense Oligonucleotides Therapy in ALS

Timothy Miller

 

2:30 pm Break

 

3:00 pm Applications of Stem Cell Biology to Understanding ALS

Kevin Eggan

 

3:30 pm Immunotherapy

Al Sandrock

 

Session V – Research Directions Towards Understanding Sporadic Neurodegeneration 

 

4:00 pm Panel Discussion

Kevin Eggan, Alfred Goldberg, Leonard Guarante, Jean-Pierre Julian, Greg Petsko

 

4:45 pm Closing Remarks

 

5:00 pm Adjourn