B Cells In Autoimmunity and Multiple Sclerosis

Thursday, November 29, 2007

 

8:00 am Registration

 

9:00 am Introductory Remarks

David Scott

 

SESSION I - B Cells as Effectors and Regulators in Autoimmunity

 

9:20 am Multiple Sclerosis: to B or not to B

Amit Bar-Or

 

10:00 am Antigen Editing by B Cells in Autoimmunity

Mark Mamula

 

10:40 am Break

 

11:00 am The Role of B Cells in Regulating CNS Inflammation

Bonnie Dittel

 

11:40 am Lunch

 

SESSION II - B cells as APC in MS/EAE

 

1:00 pm T-B Cell Interactions in Spontaneous EAE

Hartmut Wekerle

 

1:40 pm Gene Therapy for MS: Role of B Cells

David Scott

 

2:20 pm Break

 

2:40 pm Differential Effects of Anti-CD20 B Cell Depletion in Treatment of CNS Autoimmunity

Scott Zamvil

 

SESSION III- Antigen Presentation in the CNS

 

3:20 pm The Inflamed CNS as a Neo-Lymphoid Organ: Functional Identification of Dendritic Cell Subsets Promoting and Regulating Epitope Spreading

Stephen Miller

 

4:00 pm Pathologic Relevance of Ectopic B Cell Follicles in the Multiple Sclerosis Brain

Franchesca Aloisi

 

4:40 pm How B Cells Shape the Inflammatory Response in EAE

Joan Goverman

 

5:20 pm Poster Reception

 

Friday, November 30, 2007

 

7:00 - 8:00 am Breakfast

 

8:00 am Opening Remarks

Joan Goverman

 

SESSION IV - Pathogenic Role of Antibody in MS/EAE

 

8:10 am Pathogenic Autoantibodies in MS: from Demyelination to Axonal Injury

Chris Linington

 

8:50 am Effector Function of Demyelinating Abs: How Do Abs Damage the Brain?

Buchard Becher

 

9:30 am Differential Recognition of MOG by Pathogenic and Nonpathogenic Antibodies

Nancy Ruddle

 

10:10 am Break

 

SESSION V - B Cell Footprints in MS

 

10:30 am B cells and Autoantibodies in Pediatric MS

Kai Wucherpfennig

 

11:10 am Immunopathogenesis of MS and Related Disorders

Claudia Lucchinetti

 

11:50 am Characterization of B cells in MS Plaque Tissue

David Hafler

 

12:30 pm Lunch

 

SESSION VI - Lymphocyte Trafficking

 

1:30 pm A New View of Immune Surveillance in the CNS

Richard Ransohoff

 

2:10 pm Imaging Adaptive Immune Responses in Living Animals

Ulrich von Adrian

 

2:50 pm Plasma Blast Regulation During Virus-induced Demyelination

Cornelia Bergmann

 

3:30 pm Break

 

SESSION VII - B Cells in MS Therapies

 

3:50 pm CD20 Depletion in Relapsing Remitting MS: Confirmation of Activity in Phase I/II

Craig Smith

 

4:30 pm Specific Downregulation of Immune Responses as a Treatment Strategy

for T cell-mediated Autoimmune Diseases Using Genetically Modified B cells

Yacov Ron

 

5:10 pm Rituximab Use in Relapsing MS Patients Who are Sub-optimally Treated with Standard Therapies

Anne Cross

 

5:50 pm Presentation of National Multiple Sclerosis Society Poster Awards and

Closing Remarks

 

6:00 pm Adjourn